Our Published Research

Welcome to PKDERM’s “Publications” page, where we proudly present our extensive body of published research. At PKDERM, we are dedicated to advancing the fields of biotechnology, in vitro testing, and pharmaceutical innovation. Our commitment to scientific excellence drives us to contribute to the global scientific community by sharing our insights, discoveries, and expertise.

In this section, you’ll find a comprehensive collection of research publications authored by our experts. These publications cover a wide spectrum of topics, ranging from cutting-edge in vitro testing methodologies to regulatory insights and groundbreaking discoveries in drug development. Each publication represents our ongoing efforts to enhance scientific knowledge, improve product safety and efficacy, and drive innovation.

We invite you to explore our research and delve into the wealth of knowledge that PKDERM has contributed to the scientific landscape. Our aim is not only to advance our own understanding but also to support and inspire fellow researchers, professionals, and enthusiasts in their pursuit of scientific excellence. Thank you for joining us on this journey of discovery and innovation.

  1. Barthe, M.; Gillot, L.; Perdigon, L.; Jacobs, A.; Schoonbroodt, G.; Mauhin, P.; Bouhajja, E.; Osman-Ponchet, H. Topical Probiotic Formulation Promotes Rapid Healing in Dog Keratinocyte Cells: A Promising Approach for Wound Management. Int. J. Mol. Sci. 202324, 12360. https://doi.org/10.3390/ijms241512360
  2. M Barthe, L Hertereau, N Lamghari, H Osman-Ponchet, VM Braud. Receptors and Cofactors That Contribute to SARS-CoV-2 Entry: Can Skin Be an Alternative Route of Entry?  Int. J. Mol. Sci. 2023, 24(7), 6253. https://doi.org/10.3390/ijms24076253 
  3. M Barthe, JP Thénot, H Osman-Ponchet. Effect of UVB Radiation on the Expression of ABC and SLC Drug Transporters in Human Dermal Fibroblasts. Clin Exp Dermatol Ther, 2022,  7: 193. https://doi.org/10.29011/2575-8268.100193
  4. M Barthe,  C Bavoux, F Finot, I Mouche, C Cuceu-Petrenci, A Forreryd, A Chérouvrier Hansson, H Johansson, GF. Lemkine, JP Thénot,  H Osman-Ponchet. Safety Testing of Cosmetic Products: Overview of Established Methods and New Approach Methodologies (NAMs). Cosmetics, 2021, 8, (2), 50. https://www.mdpi.com/2079-9284/8/2/50/
  5. F Endringer Pinto, C Bagger, G Kunze, N Joly‐Tonetti, JP Thénot, H Osman-Ponchet, C Janfelt.  Visualization of penetration of topical antifungal drug substances through mycosis‐infected nails by matrix assisted laser desorption ionization mass spectrometry imaging. Mycoses, 2020, 63 (8), 869-875. https://doi.org/10.1111/myc.13103
  6. M Ghannoum, L Long, G Kunze, M Sarkany, H Osman‐Ponchet. A pilot, layerwise, ex vivo evaluation of the antifungal efficacy of amorolfine 5% nail lacquer vs other topical antifungal nail formulations in healthy toenails. Mycoses, 2019, 62 (6), 494-501.  https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmyc.12896
  7. LA Clerbaux, A Paini, A Lumen, H Osman-Ponchet, AP Worth, O Fardel. Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives. Environment international, 2019, 126, 659-671. https://www.sciencedirect.com/science/article/pii/S0160412018324930
  8. AS Dugaret, B Bertino, B Gauthier, B Gamboa, M Motte, Y Rival, D Piwnica,  H Osman‐Ponchet,  V Bourdès,  J.J Voegel. An innovative method to quantitate tissue integration of hyaluronic acid-based dermal fillers.  Skin Research and Technology, 2018, 24 (3), 423-431. https://doi.org/10.1111/srt.12445
  9. H Osman-Ponchet, M Alriquet, M Kouidhi, K Sevin, A Gaborit. Use of Microneedle Device to Enhance Dermal Absorption: Study on Ex Vivo Human Skin. J Dermat Cosmetol, 2018, 2 (2), 00032. http://dx.doi.org/10.15406/jdc.2018.02.00032
  10. H Osman-Ponchet, A Gaborit, K Sevin, et al. Preteatment of skin using an abrasive skin preparation pad, a microneedling device or iontophoresis improves absorption of methyl aminolevulinate in ex vivo human skin. Photodiagnosis and Photodynamic Therapy , 2017, 20, 130-136.  http://dx.doi.org/10.1016/j.pdpdt.2017.09.006
  11. H Osman-Ponchet, A Gaborit, M Kouidhi, S Anglars, et al. Comparison of the Effect of Skin Preparation Pads on Transepidermal Water Loss in Ex Vivo Human Skin.  Dermatology and Therapy, 2017,  7 (3), 407-415. http://dx.doi.org/10.1007/s13555-017-0193-2
  12. H Osman-Ponchet, A Gaborit, JM Linget, CE Wilson. Expression of drug transporters in the human skin: comparison in different species and models and its implication for drug development.  ADMET and DMPK, 2017, 5 (2), 75-84. http://dx.doi.org/10.5599/admet.5.2.390
  13. H Osman-Ponchet, K Sevin, A Gaborit, M Kouidhi, et al. Lack of effect of selected sunscreens applied on ex vivo human skin for 5-methyl-aminolevulinic acid penetration and protoporphyrin IX photoactivation. Photodiagnosis and Photodynamic Therapy, 2017, 17, 75-81. http://dx.doi.org/10.1016/j.pdpdt.2016.11.012
  14. H Osman-Ponchet, K Sevin, A Gaborit, N Wagner, M Poncet. Fixed-combination gels of adapalene and benzoyl peroxide provide optimal percutaneous absorption compared to monad formulations of these compounds: results from two in vitro studies. Dermatology and Therapy, 2017, 7 (1), 123-131. http://dx.doi.org/10.1007/s13555-016-0159-9
  15. B Sigurgeirsson, MA Ghannoum, H Osman‐Ponchet, N Kerrouche. Application of cosmetic nail varnish does not affect the antifungal efficacy of amorolfine 5% nail lacquer in the treatment of distal subungual toenail onychomycosis: results of a randomised active-controlled study and in vitro assays. Mycoses , 2016, 59 (5), 319-326. http://dx.doi.org/10.1111/myc.12473
  16. M Alriquet, K Sevin, A Gaborit, P Comby, B Ruty, H Osman-Ponchet. Characterization of SLC transporters in human skin. ADMET and DMPK , 2015, 3 (1.), 34-44. http://dx.doi.org/10.5599/admet.3.1.163
  17. H Osman-Ponchet, A Boulai, M Kouidhi, K Sevin, M Alriquet, A Gaborit, et al. Characterization of ABC transporters in human skin. Drug Metabolism and Personalized Therapy, 2014, 29 (2), 91-100. http://dx.doi.org/10.1515/dmdi-2013-0042
  18. J Lochman, T Kasparovsky, J Damborsky, H Osman, et al. Construction of Cryptogein Mutants, a Proteinaceous Elicitor from Phytophthora, with Altered Abilities To Induce a Defense Reaction in Tobacco Cells. Biochemistry, 2005, 44 (17), 6565-6572. http://dx.doi.org/10.1021/bi0502285
  19. A Lancon, D Delma, H Osman, JP Thénot, B Jannin, N Latruffe. Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process. Biochemical and biophysical research communications, 2004, 316 (4), 1132-1137. http://dx.doi.org/10.1016/j.bbrc.2004.02.164
  20. H Osman, C Murigande, A Nadakal, AM Capponi. Repression of dax-1 and induction of sf-1 expression two mechanisms contributing to the activation of aldosterone biosynthesis in adrenal glomerulosa cells. Journal of Biological Chemistry , 2002, 277 (43), 41259-41267. http://dx.doi.org/10.1074/jbc.m206595200
  21. GQ Ding, G Maume, H Osman, M Padieu, ML Milat, C Humbert, JP Blein, et al. Effects of 12 beticolins, Cercospora beticola toxins, on proliferation of ras-transformed adrenocortical cell. Acta pharmacologica Sinica, 2001, 22 (9), 769-776. https://serials.unibo.it/cgi-ser/start/en/spogli/df-s.tcl?prog_art=8455745&language=ENGLISH&view=articoli
  22. H Osman, S Vauthrin, V Mikes, ML Milat, F Panabières, A Marais, et al. Mediation of elicitin activity on tobacco is assumed by elicitin-sterol complexes. Molecular Biology of the Cell, 2001, 12 (9), 2825-2834. http://dx.doi.org/10.1091/mbc.12.9.2825
  23. H Osman, V Mikes, ML Milat, M Ponchet, D Marion, T Prange, BF Maume, et al. Fatty acids bind to the fungal elicitor cryptogein and compete with sterols. FEBS letters, 2001, 489 (1), 55-58. http://dx.doi.org/10.1016/s0014-5793(01)02078-6
  24. JL Mazet, M Padieu, H Osman, G Maume, P Mailliet, N Dereu, et al. Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase‐1 inhibitor GGTI‐298 disrupts MAP kinase activation and G1‐S transition in Ki-Ras-overexpressing transformed adrenocortical cells. FEBS letters, 1999,  460 (2), 235-240. https://doi.org/10.1016/S0014-5793(99)01355-1
  25. S Vauthrin, V Mikes, ML Milat, M Ponchet, B Maume, H Osman, JP Blein. Elicitins trap and transfer sterols from micelles, liposomes and plant plasma membranes. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1999, 1419 (2), 335-342. http://dx.doi.org/10.1016/s0005-2736(99)00083-8
  26. H Osman, JL Mazet, G Maume, BF Maume. Geranylgeranyl   as well as farnesyl moiety is transferred to Ras p21 overproduced in adrenocortical cells transformed by c-Ha-rasEJ oncogene. Biochemical and biophysical research communications, 1997, 231 (3), 789-792. http://dx.doi.org/10.1006/bbrc.1997.6183
  27. G Descotes, H Osman, JF Gallas, E Penacchio, C Moreau. Functional, biochemical, and morphological hepatobiliary effects in rats chronically exposed to a steroidal antiandrogen. Toxicology and Applied Pharmacology, 1996, 137 (1), 23-33. http://dx.doi.org/10.1006/taap.1996.0053